Effect of morphine on pulmonary blood volume in convalescents from high altitude pulmonary oedema.

Effect of frusemide on pulmonary blood volume.

Intracardiac frusemide given to seven patients recovering from high-altitude pulmonary oedema caused a significant reduction in the pulmonary blood volume before the onset of diuresis. This supports the suggestion that the mobilization of fluid from the pulmonary circuit is responsible for the relief of symptoms in some patients with pulmonary oedema even when a diuresis does not occur.

Unravelling the Pathogenesis of Severe COVID-19 Pneumonia: Are There Possible Insights From High Altitude?

High altitude-induced pulmonary oedema.

Almost one mountain trekker or climber out of two develops several symptoms of high altitude illness after a rapid ascent (> 300 m/day) to an altitude above 4000 m. Individual susceptibility is the most important determinant for the occurrence of high altitude pulmonary oedema (HAPE). Symptoms associated with HAPE are incapacitating fatigue, chest tightness, dyspnoea at the slightest effort, or...

No evidence for interstitial lung oedema by extensive pulmonary function testing at 4,559 m.

The aim of the present study was to better understand previously reported changes in lung function at high altitude. Comprehensive pulmonary function testing utilising body plethysmography and assessment of changes in closing volume were carried out at sea level and repeatedly over 2 days at high altitude (4,559 m) in 34 mountaineers. In subjects without high-altitude pulmonary oedema (HAPE), t...

Ultrastructure of high altitude pulmonary oedema.

Heath, D., Moosavi, H., and Smith, P. (1973). Thorax, 28, 694-700. Ultrastructure of high altitude pulmonary oedema. When rats are exposed for 12 hours to simulated high altitude corresponding to the summit of Mount Everest, they develop ultrastructural changes in the lungs. These consist of the formation and protrusion of multiple endothelial vesicles into the pulmonary capillaries. It seems l...